Acid-resistant Capsules (HPMC Capsules) — QUALI-V®-S

Health food capsules

Acid-resistant Capsules (HPMC Capsules)

Acid-resistant Capsules (HPMC Capsules) — QUALI-V®-S

Hydroxypropyl methylcellulose (HPMC) -based capsules that are resistant to dissolution in acidic solutions.

Acid-resistant Capsules (HPMC Capsules) — QUALI-V®-S

Product Overview

  • QUALI-V®-S capsules are suited to acid-sensitive materials, as they do not dissolve readily in acidic solutions.
  • Hydroxypropyl methylcellulose (HPMC) is 100% plant-based and QUALI-V®-S includes no animal-sourced raw materials whatsoever.
  • Less affected by mechanical strength by air humidity and suitable for hygroscopic APIs.
  • Free of allergen (28 raw materials identified as allergens in Japan).
  • It is possible to fill with a combination of two or more types of preparations, such as solid, oily liquid, and semi-solid preparations (oily liquid and semi-solid preparations need the band sealing).

QUALI-V®-S capsules are ideal for the following substances.

  1. Substances for which the effectiveness of their ingredients is reduced by acidity: Lactobacillus and Bifidobacterium species
  2. Substances with a powerful irritant effects on the gastric mucosa: hot peppers (capsaicin), garlic, etc.
  3. Substances that may cause bad breath: garlic, DHA/EPA (fish oils), shark liver oil, etc.

Color Lineup

The following capsule colors are available in our standard lineup.

  • WhiteWhite
  • ClearClear

Please contact us for inquiries about capsule stock.

Capsule Sizes

Available in 3 sizes, from 1 to 3.

Capsule Sizes
Size (♯) 1 2 3
Volume (mL) 0.49 0.37 0.28

Packaging Quantities (number included)

The standard numbers of capsules packed in each case for outside of Japan are as follows.

Capsule size (♯) Standard quantities
1 Transparent capsules 100,000
Opaque capsules 125,000
2 150,000
3 200,000

Test Data

Dissolution Test

QUALI-V®-S capsules do not dissolve readily in 1st fluid for dissolution test (simulating gastric fluid).

Test Data
Source: In-house data
Test conditions

Capsule size: ♯1

Apparatus: Paddle method, 50 rpm, UV detection

Dissolution media: water, 1st fluid for dissolution test, or 2nd fluid for dissolution test, 900 mL each

Capsule fill formulation: 20% acetaminophen mixture

Fill weight: 300 mg


We prepare accreditations and/or certifications for QUALI-V®-S. For further reference, please contact us for further information.

Kosher Certification (Copy) GMO Statement Allergen Statement
Titanium Oxide Statement Agricultural Chemical Residues in Foods Statement Food Utensils, Containers, and Packaging Statement
Gluten Statement Irradiation Statement SDS
Capsule Specifications Flow of Manufacturing Capsules Test Methods
Capsule Theoretical Formula Nutrition information COA Sample

Related Products


QUALI-V is a registered trademark of Qualicaps in China, India, US, Canada, EU, Switzerland, and UK.

Inquiries / Downloads

For inquiries about capsules or equipment, or to download reference materials, click on the links below.